In college, I remember being blown away by a huge, physical map of metabolic pathways our Biochemistry professor once brought into class. It looked like this:
Here it is online. Kinda like a Google Maps of cellular reactions. It was impressed upon us that the interior of a cell (especially a eukaryotic one) is a really, really busy and tight and ‘goopy’ place: “crowded, compartmentalized, sticky, spatially inhomogeneous”. As that paper notes, this messy, “macromolecular crowding” helps your proteins fold properly (among several other factors.) This was a bit hard for me to appreciate since, up to then, I was only accustomed to images of cells from a light microscope or vastly simplified illustrations school texts.
I was somehow reminded of all of that after seeing some astounding paintings by Professor David S. Goodsell (Wiki, Twitter, Website). He calls the series “Molecular Landscapes.” Here are a few related to the pandemic we’ve been through.
SARS-CoV-2 and Neutralizing Antibodies, 2020
Acknowledgement: David S. Goodsell, RCSB Protein Data Bank and Springer Nature; doi: 10.2210/rcsb_pdb/goodsell-gallery-025. The painting was commissioned for the cover of a special COVID-19 issue of Nature, presented 20 August 2020, and is currently in the collection of the Cultural Programs of the National Academy of Sciences.
(Unknown Title)
Acknowledgement: Illustration by David S. Goodsell
Coronavirus, 2020
Acknowledgement: Illustration by David S. Goodsell, RCSB Protein Data Bank; doi: 10.2210/rcsb_pdb/goodsell-gallery-019. This painting depicts a coronavirus just entering the lungs, surrounded by mucus secreted by respiratory cells, secreted antibodies, and several small immune systems proteins. The virus is enclosed by a membrane that includes the S (spike) protein, which will mediate attachment and entry into cells, M (membrane) protein, which is involved in organization of the nucleoprotein inside, and E (envelope) protein, which is a membrane channel involved in budding of the virus and may be incorporated into the virion during that process. The nucleoprotein inside includes many copies of the N (nucleocapsid) protein bound to the genomic RNA.
SARS-CoV-2 Fusion, 2020
Acknowledgement: Illustration by David S. Goodsell, RCSB Protein Data Bank; doi: 10.2210/rcsb_pdb/goodsell-gallery-026. This painting depicts the fusion of SARS-CoV-2 (magenta) with an endosomal membrane (green), releasing the viral RNA genome into the cell cytoplasm (blue), where it is beginning to be translated by cellular ribosomes to create viral polyproteins. The painting includes speculative elements that are designed to highlight the process, most notably, multiple states of the viral spike protein are shown.
SARS-CoV-2 mRNA Vaccine, 2020
Acknowledgement: Illustration by David S. Goodsell, RCSB Protein Data Bank; doi: 10.2210/rcsb_pdb/goodsell-gallery-027. Messenger RNA (mRNA) vaccines developed for the COVID-19 pandemic are composed of long strands of RNA (magenta) that encode the SARS-CoV-2 spike surface glycoprotein enclosed in lipids (blue) that deliver the RNA into cells. Several different types of lipids are used, including familar lipids, cholesterol, ionizable lipids that interact with RNA, and lipids connected to polyethylene glycol chains (green) that help shield the vaccine from the immune system, lengthening its lifetime following administration. In this idealized illustration, all of the lipids are arranged in a simple circular bilayer that surrounds the mRNA and the PEG strands have both extended and folded conformations. In reality, the structure may be less regular, as suggested in the NanoLetters paper […]
As of the 4th of February 2021, and under its Governor’s wise, prescient, expert and data-driven leadership, Iowa ranks 47th in the nation for the number of vaccines administered 💯
Iowa has received 446,825 doses of vaccine and has administered 266,777 doses, or just under 60% of vaccines received, the CDC reported Thursday. The state has the sixth-lowest rate of administered vaccine per capita in the nation.
“We’re averaging about 60% in getting the vaccines administered and that’s not where we need to be,” Reynolds said. “We want to do better. We know we can do better.”
We certainly can. The number of COVID-related deaths in Iowa stood at 5,033 as of this date. The very next day, our fearless Governor signed a Public Health Disaster proclamation that, compared to its predecessor, ended mask mandates and removed all limits on public gatherings.
In time for the Super Bowl, of course.
All of these relaxations at this stage of the pandemic make about as much sense as wearing underwear constructed out of nails and thumbtacks. If anything, Iowa should be enhancing precautions during the next several weeks, as long as the colder temperatures and drier air may be driving greater transmission of the virus. What is the scientific justification for what Reynolds has declared in the emergency declaration? It’s unclear. Seems like someone may owe Iowa an explanation.
Other the the usual bullshit conservative pabulum about freedom and small businesses and bootstraps and moochers and handouts, I don’t expect any explanation that makes sense.
any history of COVID-19 in the US should really start off with an anecdote about how the chernobyl miniseries came out in 2019 and there was immediately a conclave of pundits smugly declaring that we would never respond to a disaster with such epic and malicious mismanagement
I’m on the phone with every f–king studio at night, insurance companies, producers, and they’re looking at us and using us to make their movies. We are creating thousands of jobs you motherf–kers.
I don’t ever want to see it again, ever! And if you don’t do it you’re fired, if I see you do it again you’re f–king gone. And if anyone in this crew does it – that’s it, and you too and you too. And you, don’t you ever f–king do it again.
That’s it! No apologies. You can tell it to the people that are losing their f-ing homes because our industry is shut down. It’s not going to put food on their table or pay for their college education.
That’s what I sleep with every night. The future of this f–king industry! So I’m sorry I am beyond your apologies. I have told you and now I want it and if you don’t do it you’re out. We are not shutting this f–king movie down! Is it understood?
If I see it again you’re f–king gone — and you are — so you’re going to cost him his job, if I see it on the set you’re gone and you’re gone.
That’s it. Am I clear?
Do you understand what I want? Do you understand the responsibility that you have? Because I will deal with your reason. And if you can’t be reasonable and I can’t deal with your logic, you’re fired. That’s it. That is it.
I trust you guys to be here. That’s it. That’s it guys. Have a little think about it. . . [inaudible].
That’s what I think of Universal and Paramount. Warner Brothers. Movies are going because of us. If we shut down it’s going to cost people f–king jobs, their home, their family. That’s what’s happening.
All the way down the line. And I care about you guys, but if you’re not going to help me you’re gone. OK? Do you see that stick? How many meters is that?
When people are standing around a f–king computer and hanging out around here, what are you doing? And if they don’t comply then send their names to Matt Spooner. That’s it.
President Trump’s lawyer Jenna Ellis has informed associates she tested positive for the coronavirus, multiple sources tell Axios, stirring West Wing fears after she attended a senior staff Christmas party on Friday.
“She had the nerve to show up at the senior staff Christmas party knowing everyone was furious with her for constantly stirring Trump up with nonsense,” said a senior administration official.
Mr. Giuliani appeared on Fox News earlier on Sunday. Speaking with the host Maria Bartiromo via satellite, Mr. Giuliani repeated baseless claims about fraud in Georgia and Wisconsin on “Sunday Morning Futures.” When asked if he believed Mr. Trump still had a path to victory, he said, “We do.”
On Monday, Gov. Gretchen Whitmer of Michigan said that a four-hour hearing last Wednesday with a roomful of unmasked witnesses had all the ingredients of a super-spreader event.
“That hearing last week was reckless, it was unnecessary and didn’t change a thing,” she said. “It’s action like this that threatens our ability to open up some of these businesses.”
Informed Choice Iowa is a group that “unites Iowans seeking to preserve their medical freedoms.” They are “pro-science” folk that count “ex-vaxxers”, “selective vaxxers”, “non-vaxxers”, and “vaxxers” among their members. I’m guessing that this list doesn’t include a single practicing physician.
And here’s them celebrating their freedoms, by which they mean a blatant disregard for the science they claim to love and the Iowans they claim to serve. Need confirmation but I hear that eating at least two tubes of toothpaste is on the agenda for their next idiot congregation.
Reynolds said election victories for Republicans in the state this week show Iowans support her approach. “It was a validation of our balanced response to COVID-19, one that is mindful of both public health and economic health,” Reynolds said.
Because political victories, not cases or deaths, should inform and ‘validate’ one’s strategy when dealing with a raging pandemic.
is a simple and aptly-named COVID tracker that uses data from Johns Hopkins. As of September 1st 2020, my state of Iowa is #1 (woohoo!) with a 7-day infection rate of 261/100,000 people (“there might be 2 to 6 times as many recent infections”) and an R0 rate of 1.7. “Over the past 30 days, 246 people in Iowa have died of Covid-19. If Iowa remains on its current trajectory, expect to see more than three times as many deaths from Covid-19 over the next 30 days.” That’ll show 'em.
Yep. And the tweet was in the context of school openings, but college towns like Ames and Iowa City, are no exceptions (like she continues.) I say we continue to doubt the science, exercise absolutely no discipline in the interest of the economy (because the Communist Kiwis maintain zero interest in restoring theirs as quickly as possible), yell at people who wear masks, fight Big Government telling us what to do, expect maturity and restraint from children and teenagers, have no bloody plan, defend our effete leaders who institute weak policies that are too little and too late, control the numbers and the narrative, and just continue to be awesome ♥️ That’ll show 'em. We’re only beginning to get tired of winning folks.
BURR: I don’t want to start this bullshit. I’m not gonna sit here with no medical degree, listening to you with no medical degree, with an American flag behind you smoking a cigar, acting like we know what’s up, better than the CDC. All I do, is I watch the news once every two weeks - I’m like, “Mask or no mask? Still mask? Alright, mask!” That’s all I give a fuck about. I don’t care. I just love how wearing a mask became like this fucking like soft thing that you were doing… like being courteous…”
BURR: Why is it for bitches? That’s just so stupid.
ROGAN: (Fakes weak cough)
BURR: Oh God you’re so tough with your fucking open nose and throat and your five o’clock shadow. This is a man right here! A man doesn’t wear a mask.
Rogan’s immediate response somehow reminded me of the “infantile phallocentric Nietzscheanism that is destroying modern human culture” from one of my favorite articles.
Found this map when Googling “coronavirus india”. Looks like it’s maintained by the WHO and is pretty up-to-date. They have a daily update page.
At the time of this writing, there are 110,029 confirmed cases, with 3,817 deaths in 105 countries. China, South Korea, Iran, France, and Germany account for 95% of the total number of cases and in that order.
